Cognitive and Brain Reserve Protects Memory From Early Alzheimer’s
June 4, 2026
A recently published study investigated why some people remain cognitively healthy despite early Alzheimer’s‑related brain changes. The study was a collaboration between Murdock University in Australia and Advent Health. An estimated 20% to 30% of adults aged 65 to 75 exhibit evidence of AD pathology without measurable cognitive impairment. 1
The study specifically looked at the association between AD pathology and cognitive function to determine if the relationship could be modified by cognitive reserve (years of education and socioeconomic status) and brain reserve (brain-predicted age difference, and a volumetric AD signature2).
